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Moreover, it is estab- lished that depending on a microenvironment the stem cells are able to get through haemopoetic/mesenchymal barrier as possess to high plasticity concerning differen- tiation and transdifferentiation

The duration of the therapeutic effect is dictated by the residency time of the drug within the lung/receptor site, which can be manipulated by changing the chemical properties of the drugs delivered via inhaled delivery devices (Labiris and Dolovich 2003)